Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19415208 | 0.80 | ALDH1A1 (0.44) | ABL1FYN | |
| SCHEMBL19415191 | 0.78 | RPS6KA3 (0.44) | — | |
| SCHEMBL19415146 | 0.73 | LMNA (0.31) | — | |
| SCHEMBL19415160 | 0.73 | RAF1 (0.32) | — | |
| SCHEMBL22625601 | 0.68 | KDR (0.42) | ABL1FYN | |
| SCHEMBL25715615 | 0.67 | ALDH1A1 (0.32) | — | |
| SCHEMBL22625562 | 0.64 | RAF1 (0.44) | ABL1FYN | |
| SCHEMBL14320151 | 0.62 | ALDH1A1 (0.33) | — | |
| SCHEMBL20008360 | 0.62 | TDO2 (0.46) | ABL1 | |
| SCHEMBL28202753 | 0.61 | DYRK1A (0.40) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271622-B1 | Heteroaryl derivatives as CFTR Modulators | VERTEX PHARMA (US) | 2017-10-04 | — | — | EP | disclosed |