Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 5/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25504336 | 0.80 | KMT2A (0.45) | MEN1KMT2ACYP2C9ALDH1A1 | |
| SCHEMBL10934217 | 0.78 | ALDH1A1 (0.44) | KMT2AALDH1A1 | |
| SCHEMBL10932989 | 0.76 | HPGD (0.41) | MEN1KMT2AALDH1A1 | |
| SCHEMBL14067799 | 0.75 | NPSR1 (0.49) | MEN1KMT2ANPSR1MGLLKDM2B | |
| SCHEMBL1639877 | 0.71 | HSD11B1 (0.57) | MEN1KMT2AMGLLALDH1A1 | |
| SCHEMBL6183451 | 0.71 | ALDH1A1 (0.61) | MEN1KMT2AMGLLKCNH2ALDH1A1 | |
| SCHEMBL3936871 | 0.70 | RAB9A (0.51) | KMT2AALDH1A1 | |
| SCHEMBL17182643 | 0.70 | APEX1 (0.44) | MEN1KMT2ACYP2C9CYP2C19NPSR1 | |
| SCHEMBL13859070 | 0.70 | KMT2A (0.50) | MEN1KMT2ACYP2C9CYP2C19NPSR1 | |
| SCHEMBL31286068 | 0.69 | KMO (0.51) | MEN1KMT2ACYP2C9MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2709985-B1 | AMINE DERIVATIVES AS POTASSIUM CHANNEL BLOCKERS | BIONOMICS LTD (AU) | 2017-10-04 | — | — | EP | disclosed |