Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19672055 | 0.89 | DRD2 (0.31) | DRD2 | |
| SCHEMBL19416917 | 0.80 | PYGL (0.31) | — | |
| SCHEMBL19671830 | 0.79 | ALDH1A1 (0.46) | — | |
| SCHEMBL19416920 | 0.78 | — | — | |
| SCHEMBL19671998 | 0.77 | KAT6A (0.39) | — | |
| SCHEMBL19672008 | 0.66 | KCNK2 (0.34) | — | |
| SCHEMBL19672082 | 0.66 | KDM4E (0.37) | — | |
| SCHEMBL23867056 | 0.65 | LRRK2 (0.35) | — | |
| SCHEMBL19671958 | 0.64 | ALDH1A1 (0.40) | — | |
| SCHEMBL19688920 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964221-B1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-2964220-B1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME (US) | 2017-10-04 | — | — | EP | disclosed |