Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873766 | 0.97 | CCNK (0.47) | CCNKCCNA2CDK2CDK12LMNA | |
| SCHEMBL1539141 | 0.85 | NPC1 (0.42) | CCNKCCNA2CDK2CDK12CHRM2 | |
| SCHEMBL21152972 | 0.79 | GPR119 (0.44) | CCNKCCNA2CDK2CDK12PGR | |
| SCHEMBL19418249 | 0.78 | CCNK (0.40) | CCNKCCNA2CDK2CDK12PGR | |
| SCHEMBL8920546 | 0.77 | LMNA (0.55) | LMNACHRM2CHRM3RAB9ANPC1 | |
| SCHEMBL11807077 | 0.75 | LMNA (0.50) | LMNACHRM2CHRM3RAB9ANPC1 | |
| SCHEMBL3908885 | 0.75 | LMNA (0.50) | LMNACHRM2CHRM3RAB9ANPC1 | |
| SCHEMBL10533797 | 0.75 | MAOA (0.38) | CCNKCCNA2CDK2CDK12RAB9A | |
| SCHEMBL27302165 | 0.75 | MAOA (0.44) | CCNKCCNA2CDK2CDK12RAB9A | |
| SCHEMBL6601536 | 0.75 | KDM4E (0.64) | LMNACHRM2CHRM3RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925757-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | NOVARTIS AG (CH) | 2017-10-04 | — | — | EP | disclosed |