Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.53 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.53 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.52 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.49 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6293628 | 0.85 | THRA (0.55) | CYP1A1CYP1B1MAPTGAASLC5A1 | |
| SCHEMBL27540915 | 0.77 | NLRP3 (0.54) | CYP1A1CYP1B1MAPTGAASLC5A1 | |
| SCHEMBL20576964 | 0.77 | MAPT (0.54) | CYP1A1CYP1B1MAPTGAASLC5A1 | |
| SCHEMBL12807524 | 0.75 | HPGD (0.69) | AKR1C3AKR1C2AKR1C1AKR1C4HSPD1 | |
| SCHEMBL25372849 | 0.72 | ABCB1 (0.48) | PTPN1 | |
| SCHEMBL10701348 | 0.72 | AKR1C3 (0.61) | AKR1C3AKR1C2AKR1C1AKR1C4HSPD1 | |
| SCHEMBL11708450 | 0.72 | AKR1C4 (0.60) | AKR1C3AKR1C2AKR1C1AKR1C4HSPD1 | |
| Dihydrochalcone SCHEMBL29359372 | 0.72 | CYP19A1 (0.80) | CYP1A1CYP1B1MAPTGAASLC5A1 | |
| Dihydrochalcone SCHEMBL2827303 | 0.72 | CYP19A1 (0.80) | CYP1A1CYP1B1MAPTGAASLC5A1 | |
| SCHEMBL30736448 | 0.71 | CYP1A1 (0.65) | CYP1A1CYP1B1MAPTGAASLC5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | TP53, NQO1, SHMT2 | AKR1C3 2701/4885AKR1C2 2585/4885AKR1C1 2535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.