Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.73 |
| ▸ | NPC1 | O15118 | 4/20 | 0.73 |
| ▸ | RAB9A | P51151 | 4/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | TPH1 | P17752 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.58 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17831085 | 0.90 | KMT2A (0.62) | MAPTSMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL12259206 | 0.89 | KMT2A (0.61) | MAPTSMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL16602947 | 0.78 | NPC1 (0.83) | MAPTSMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL1430356 | 0.78 | NR1H4 (0.73) | MAPTSMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL15920066 | 0.77 | KMT2A (1.00) | MAPTSMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL12310047 | 0.77 | KMT2A (0.55) | MAPTSMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL12267142 | 0.77 | RAB9A (0.67) | MAPTSMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL20777159 | 0.76 | TPH1 (1.00) | MAPTSMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL20777161 | 0.76 | TPH1 (1.00) | MAPTSMN1; SMN2NPC1RAB9ANPSR1 | |
| SCHEMBL14881833 | 0.76 | MAPT (0.62) | MAPTSMN1; SMN2NPC1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | TP53, NQO1, SHMT2 | MAPT 1762/4885SMN1; SMN2 595/4885NPC1 715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.