Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.61 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7938406 | 0.86 | TSHR (0.67) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL19420173 | 0.81 | MAPT (0.58) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL10986702 | 0.74 | ALDH1A1 (0.57) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL5145754 | 0.73 | KMT2A (0.62) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL11508333 | 0.72 | SMN1; SMN2 (0.57) | APOBEC3GERAP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8526073 | 0.71 | KMT2A (0.82) | APOBEC3GERAP1SMN1; SMN2NPC1RAB9A | |
| Bromide SCHEMBL11197730 | 0.71 | ALDH1A1 (0.55) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL11887819 | 0.71 | MPO (0.74) | SMN1; SMN2RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL21765474 | 0.71 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL2959279 | 0.70 | HIF1A (0.82) | SMN1; SMN2NPC1RAB9AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | UNITY BIOTECHNOLOGY, INC. (US) | 2019-02-05 | — | — | US | disclosed |
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | TP53, NQO1, SHMT2 | APOBEC3G 3510/4885ERAP1 1048/4885SMN1; SMN2 595/4885 |
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | TP53, CDKN1A, GLA | APOBEC3G 1721/4885ERAP1 1448/4885SMN1; SMN2 839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.