Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19422692 | 0.78 | P4HTM (0.53) | VNN1RPS6KB1AURKAKDM4EKDM4C | |
| SCHEMBL19422718 | 0.77 | KDM4C (0.62) | RPS6KB1KDM4EKDM4CKDM6BKDM4A | |
| SCHEMBL15818650 | 0.77 | KDM4C (0.69) | KDM4EKDM4CKDM6BKDM4AKDM4D | |
| SCHEMBL19422720 | 0.77 | KDM4C (0.53) | RPS6KB1AURKAKDM4EKDM4CKDM6B | |
| SCHEMBL19422739 | 0.74 | KDM4E (0.63) | RPS6KB1AURKAKDM4EKDM4CKDM6B | |
| SCHEMBL19422738 | 0.73 | KDM4C (0.53) | KDM4EKDM4CMEN1KMT2AALDH1A1 | |
| SCHEMBL19422707 | 0.73 | KMT2A (0.50) | RPS6KB1KDM4EKDM4CKDM6BKDM4A | |
| SCHEMBL27873365 | 0.73 | MEN1 (0.55) | VNN1RPS6KB1AURKAKDM4EAKT1 | |
| SCHEMBL20956866 | 0.71 | KDM4C (0.67) | KDM4EKDM4CMEN1KMT2AALDH1A1 | |
| SCHEMBL20956878 | 0.70 | RPS6KB1 (0.47) | RPS6KB1AURKAAKT1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190135765-A1 | NOVEL PYRIMIDINE-4-CARBOXYLIC ACID DERIVATIVE HAVING ANTICANCER ACTIVITY | INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY (KR) | 2019-05-09 | — | — | US | claimed |
| US-20190135765-A1 | NOVEL PYRIMIDINE-4-CARBOXYLIC ACID DERIVATIVE HAVING ANTICANCER ACTIVITY | INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY (KR) | 2019-05-09 | — | — | US | disclosed |
| US-20190135765-A1 | NOVEL PYRIMIDINE-4-CARBOXYLIC ACID DERIVATIVE HAVING ANTICANCER ACTIVITY | INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY (KR) | 2019-05-09 | — | — | US | disclosed |
| WO-2017171421-A1 | NOVEL PYRIMIDINE-4-CARBOXYLIC ACID DERIVATIVE HAVING ANTICANCER ACTIVITY | 한국과학기술연구원 | 2017-10-05 | — | — | WO | disclosed |
| US-20150322068-A1 | SUBSTITUTED XANTHINE DERIVATIVES | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2015-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322068-A1 | SUBSTITUTED XANTHINE DERIVATIVES | XDH, HPRT1, CXCR3 | VNN1 1528/4885RPS6KB1 4718/4885AURKA 4690/4885 |
| US-20190135765-A1 | NOVEL PYRIMIDINE-4-CARBOXYLIC ACID DERIVATIVE HAVING ANTICANCER ACTIVITY | DPYD, TYMS, TYMP | VNN1 3811/4885RPS6KB1 2882/4885AURKA 121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.