Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.53 |
| ▸ | KDM5A | P29375 | 3/20 | 0.53 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 8/20 | 0.48 |
| ▸ | AKT1 | P31749 | 3/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19422692 | 0.84 | P4HTM (0.53) | KDM4CKDM5BRPS6KB1AKT1AURKA | |
| SCHEMBL20956878 | 0.79 | RPS6KB1 (0.47) | RPS6KB1AKT1CLK4AURKAFFAR1 | |
| SCHEMBL15818434 | 0.79 | KDM4C (0.73) | KDM4CKDM5AKDM5BCDC7ROCK2 | |
| SCHEMBL19422718 | 0.78 | KDM4C (0.62) | KDM4CKDM5BRPS6KB1AKT1CDC7 | |
| SCHEMBL19422708 | 0.77 | VNN1 (0.52) | KDM4CRPS6KB1AKT1CDC7MAP4K4 | |
| SCHEMBL19422707 | 0.76 | KMT2A (0.50) | KDM4CKDM5BRPS6KB1AKT1FFAR1 | |
| SCHEMBL20956885 | 0.76 | ASPH (0.46) | KDM4CRPS6KB1AURKAKDM4E | |
| SCHEMBL19422691 | 0.74 | ATM (0.39) | KDM4CKDM5AKDM5BRPS6KB1AKT1 | |
| SCHEMBL19422706 | 0.73 | KDM4E (0.58) | KDM4CRPS6KB1AURKAFFAR1KDM4E | |
| SCHEMBL19422739 | 0.72 | KDM4E (0.63) | KDM4CRPS6KB1AURKAAURKBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190135765-A1 | NOVEL PYRIMIDINE-4-CARBOXYLIC ACID DERIVATIVE HAVING ANTICANCER ACTIVITY | INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY (KR) | 2019-05-09 | — | — | US | claimed |
| US-20190135765-A1 | NOVEL PYRIMIDINE-4-CARBOXYLIC ACID DERIVATIVE HAVING ANTICANCER ACTIVITY | INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY (KR) | 2019-05-09 | — | — | US | disclosed |
| US-20190135765-A1 | NOVEL PYRIMIDINE-4-CARBOXYLIC ACID DERIVATIVE HAVING ANTICANCER ACTIVITY | INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY (KR) | 2019-05-09 | — | — | US | disclosed |
| WO-2017171421-A1 | NOVEL PYRIMIDINE-4-CARBOXYLIC ACID DERIVATIVE HAVING ANTICANCER ACTIVITY | 한국과학기술연구원 | 2017-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190135765-A1 | NOVEL PYRIMIDINE-4-CARBOXYLIC ACID DERIVATIVE HAVING ANTICANCER ACTIVITY | DPYD, TYMS, TYMP | KDM4C 1220/4885KDM5A 1910/4885KDM5B 1782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.