Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080954 | 0.90 | ALDH1A1 (0.51) | HPGDALDH1A1MAPK1CYP3A4TUBB4A | |
| SCHEMBL8471042 | 0.84 | MTNR1A (0.46) | HPGDALDH1A1MAPK1CYP3A4MEN1 | |
| SCHEMBL30407941 | 0.81 | EDNRA (0.52) | AKR1C3AKR1C2MEN1KMT2ANPC1 | |
| SCHEMBL11175864 | 0.80 | ALDH1A1 (0.62) | HPGDALDH1A1MAPK1CYP3A4CYP1A2 | |
| SCHEMBL19424137 | 0.79 | ALDH1A1 (0.61) | HPGDALDH1A1MAPK1CYP3A4CYP1A2 | |
| SCHEMBL29083009 | 0.79 | CYP1A2 (0.45) | ALDH1A1CYP1A2LMNASLC6A2SLC6A3 | |
| SCHEMBL8484733 | 0.78 | ALDH1A1 (0.49) | HPGDALDH1A1MAPK1CYP3A4CYP1A2 | |
| SCHEMBL11705929 | 0.78 | PDE7A (0.48) | HPGDALDH1A1MAPK1LMNAMAPT | |
| SCHEMBL11758498 | 0.78 | AKR1C3 (0.44) | ALDH1A1CYP3A4CYP1A2CYP2C19LMNA | |
| SCHEMBL2417850 | 0.77 | SIRT1 (0.67) | HPGDALDH1A1MAPK1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999025707-A1 | 2-ARYLBENZO[b]THIOPHENES USEFUL FOR THE TREATMENT OF ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 1999-05-27 | — | — | WO | disclosed |