Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EDNRA | P25101 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8471042 | 0.93 | MTNR1A (0.46) | ALDH1A1CYP3A4HPGDMAPK1MTNR1A | |
| SCHEMBL8470680 | 0.90 | HPGD (0.53) | ALDH1A1CYP3A4HPGDMAPK1MTNR1A | |
| SCHEMBL30407941 | 0.88 | EDNRA (0.52) | MTNR1AMTNR1BHSP90AA1NPC1MEN1 | |
| SCHEMBL13921306 | 0.80 | EDNRA (0.46) | ALDH1A1HPGDMAPK1MTNR1AMTNR1B | |
| SCHEMBL11175864 | 0.79 | ALDH1A1 (0.62) | ALDH1A1CYP3A4HPGDMAPK1NPC1 | |
| SCHEMBL19424137 | 0.78 | ALDH1A1 (0.61) | ALDH1A1CYP3A4HPGDMAPK1NPC1 | |
| SCHEMBL5030912 | 0.77 | EDNRA (0.55) | HPGDMTNR1AMTNR1BHSP90AA1NPC1 | |
| SCHEMBL4805875 | 0.76 | HPGD (0.62) | ALDH1A1HPGDMTNR1AMTNR1BNPC1 | |
| SCHEMBL21248520 | 0.75 | SIRT1 (0.62) | HPGDMTNR1AMTNR1BHSP90AA1NPC1 | |
| SCHEMBL10358495 | 0.75 | KMT2A (0.52) | ALDH1A1HPGDMTNR1AMTNR1BHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920863-B1 | The use of 2-Aryl-3-aroylbenzo(b)thiophenes for the treatment of estrogen deprivation syndrome | LILLY CO ELI (US) | 2003-07-09 | — | — | EP | disclosed |
| US-6403615-B1 | TREATS OSTEOPOROSIS, HYPERLIPIDEMIA, AND CARDIOVASCULAR DISORDERS ASSOCIATED WITH MENOPAUSE; SIDE EFFECT REDUCTION COMPARED TO ESTROGEN-REPLACEMENT THERAPY | ELI LILLY AND COMPANY | 2002-06-11 | — | — | US | disclosed |
| US-6395769-B1 | ACTIVATION ESTROGEN; THERAPY FOR OSTEOPOROSIS, ANTILIPEMIC AGENTS | ELI LILLY AND COMPANY | 2002-05-28 | — | — | US | disclosed |
| US-6156786-A | ANTIESTROGENS | ELI LILLY AND COMPANY (US) | 2000-12-05 | — | — | US | disclosed |
| US-6096781-A | 2-PHENYL-1-BENZOTHIOPHENE DERIVATIVES ARE USEFUL FOR TREATMENT OF OSTEOPOROSIS AND HYPERLIPEMIA | ELI LILLY AND COMPANY (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0920863-A1 | 2-Aryl-3-aroylbenzo(b)thiophenes useful for the treatment of estrogen deprivation syndrome | ELI LILLY AND COMPANY (US) | 1999-06-09 | — | — | EP | disclosed |
| EP-0920862-A1 | 2-Arylbenzo b thiophenes useful for the treatment of estrogen deprivation syndrome | ELI LILLY AND COMPANY (US) | 1999-06-09 | — | — | EP | disclosed |
| WO-1999025707-A1 | 2-ARYLBENZO[b]THIOPHENES USEFUL FOR THE TREATMENT OF ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 1999-05-27 | — | — | WO | disclosed |
| WO-1999025706-A1 | 2-ARYL-3-AROYLBENZO[B]THIOPHENES USEFUL FOR THE TREATMENT OF ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 1999-05-27 | — | — | WO | disclosed |