Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOXO1 | Q12778 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 12/20 | 0.41 |
| ▸ | RAB9A | P51151 | 12/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18671143 | 0.92 | ESR1 (0.43) | FOXO1NPC1RAB9ADYRK1AKDM4E | |
| SCHEMBL19287942 | 0.92 | ESR1 (0.48) | FOXO1NPC1RAB9ADYRK1AKDM4E | |
| SCHEMBL19155375 | 0.85 | RIPK1 (0.46) | FOXO1 | |
| SCHEMBL19557533 | 0.85 | NPC1 (0.53) | FOXO1NPC1RAB9ADYRK1AKDM4E | |
| SCHEMBL18880102 | 0.84 | ESR1 (0.49) | NPC1RAB9ADYRK1AKDM4EALDH1A1 | |
| SCHEMBL21966181 | 0.81 | DYRK1A (0.41) | FOXO1NPC1RAB9ADYRK1AKDM4E | |
| SCHEMBL20022978 | 0.81 | DYRK1A (0.43) | FOXO1NPC1RAB9ADYRK1AKDM4E | |
| SCHEMBL21099202 | 0.80 | NPC1 (0.50) | NPC1RAB9ADYRK1AKDM4EALDH1A1 | |
| SCHEMBL23507947 | 0.79 | DYRK1A (0.39) | FOXO1NPC1RAB9ADYRK1AKDM4E | |
| SCHEMBL21298764 | 0.78 | RIPK1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530175-B2 | Method for preparation of fluoro alkylated compounds by homogeneous Ni catalysis | ARXADA AG (CH) | 2022-12-20 | — | — | US | disclosed |
| US-20220041530-A1 | Method for Preparation of Fluoro Alkylated Compounds by Homogeneous NI Catalysis | LONZA LTD (CH) | 2022-02-10 | — | — | US | disclosed |
| US-10183012-B2 | Compounds and compositions and methods of use | ARDEA BIOSCIENCES, INC. (US) | 2019-01-22 | — | — | US | disclosed |
| US-20170281601-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220041530-A1 | Method for Preparation of Fluoro Alkylated Compounds by Homogeneous NI Catalysis | ABL1, AFF2, NAF1 | FOXO1 3292/4885NPC1 329/4885RAB9A 655/4885 |
| US-11530175-B2 | Method for preparation of fluoro alkylated compounds by homogeneous Ni catalysis | ABL1, AFF2, NAF1 | FOXO1 3292/4885NPC1 329/4885RAB9A 655/4885 |
| US-10183012-B2 | Compounds and compositions and methods of use | XDH, PON1, OAT | FOXO1 2730/4885NPC1 732/4885RAB9A 3068/4885 |
| US-20170281601-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | XDH, PON1, GLS | FOXO1 2364/4885NPC1 561/4885RAB9A 2885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.