Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPS1 | P31327 | 10/20 | 0.70 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | GPR6 | P46095 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30514010 | 1.00 | CPS1 (0.70) | CPS1KDM2BMEN1KMT2APARP10 | |
| SCHEMBL30513999 | 0.92 | CPS1 (0.75) | CPS1GPR6 | |
| SCHEMBL30323172 | 0.87 | CPS1 (0.68) | CPS1MEN1KMT2A | |
| SCHEMBL20524600 | 0.87 | CPS1 (0.68) | CPS1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL30323144 | 0.86 | CPS1 (0.67) | CPS1MEN1KMT2A | |
| SCHEMBL4113759 | 0.84 | MAPT (0.61) | CPS1KDM2B | |
| SCHEMBL10963872 | 0.82 | CPS1 (0.81) | CPS1GPR6 | |
| SCHEMBL5280460 | 0.82 | KDM2B (0.49) | CPS1KDM2BMEN1KMT2A | |
| SCHEMBL30514001 | 0.81 | CPS1 (0.72) | CPS1KDM2BGPR6 | |
| SCHEMBL14477305 | 0.81 | KDM2B (0.50) | CPS1KDM2BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237624-A1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS | LABORATOIRE THERAMEX (MC) | 2011-09-29 | — | — | US | disclosed |
| US-7977364-B2 | Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents | LABORATOIRE THERMAMEX (MC) | 2011-07-12 | — | — | US | disclosed |
| EP-1812404-B1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS | THERAMEX (MC) | 2011-06-15 | — | — | EP | disclosed |
| US-20100168217-A1 | SULFAMATOBENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-01 | — | — | US | disclosed |
| US-20100168217-A1 | SULFAMATOBENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-01 | — | — | US | disclosed |
| WO-2008067892-A1 | SULPHAMATE BENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-06-12 | — | — | WO | disclosed |
| EP-1812404-A1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS | LABORATOIRE THERAMEX (MC) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006040351-A1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS | LABORATOIRE THERAMEX (MC) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168217-A1 | SULFAMATOBENZOTHIOPHENE DERIVATIVES | SULT1A1, SULT1E1, SULT2A1 | CPS1 1923/4885KDM2B 1486/4885MEN1 1845/4885 |
| US-20110237624-A1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS | ESR1, ESR2, GPER1 | CPS1 4058/4885KDM2B 1092/4885MEN1 2374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.