Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 5/20 | 0.50 |
| ▸ | CPS1 | P31327 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4839335 | 0.82 | KDM2B (0.50) | KDM2BCPS1ALDH1A1MEN1KMT2A | |
| SCHEMBL7423445 | 0.82 | KDM2B (0.50) | KDM2BCPS1ALDH1A1MEN1KMT2A | |
| SCHEMBL5280460 | 0.81 | KDM2B (0.49) | KDM2BCPS1ALDH1A1MEN1KMT2A | |
| SCHEMBL30514010 | 0.81 | CPS1 (0.70) | KDM2BCPS1MEN1KMT2A | |
| SCHEMBL1942608 | 0.81 | CPS1 (0.70) | KDM2BCPS1MEN1KMT2A | |
| SCHEMBL10192440 | 0.79 | MAPK1 (0.46) | JAK2TYK2ALDH1A1RAB9AMAPT | |
| SCHEMBL1340897 | 0.79 | NOS2 (0.48) | KDM2BCPS1ALDH1A1MEN1KMT2A | |
| SCHEMBL4113759 | 0.79 | MAPT (0.61) | KDM2BCPS1ALDH1A1RAB9AMAPT | |
| SCHEMBL4115692 | 0.79 | KDM2B (0.47) | KDM2BCPS1ALDH1A1MEN1KMT2A | |
| SCHEMBL24101676 | 0.78 | MGLL (0.45) | KDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073819-B2 | Compositions, methods of use, and methods of treatment | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073819-B2 | Compositions, methods of use, and methods of treatment | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140221473-A1 | Compositions, Methods of Use, and Methods of Treatment | UNIVERSITY OF SOUTH FLORIDA | 2014-08-07 | — | — | US | disclosed |
| US-20140221473-A1 | Compositions, Methods of Use, and Methods of Treatment | UNIVERSITY OF SOUTH FLORIDA | 2014-08-07 | — | — | US | disclosed |
| WO-2013003669-A2 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221473-A1 | Compositions, Methods of Use, and Methods of Treatment | KCNQ5, KCNQ3, KCNQ2 | KDM2B 359/4885CPS1 1536/4885JAK2 1331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.