Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.49 |
| ▸ | CPS1 | P31327 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1340897 | 0.87 | NOS2 (0.48) | KDM2BCPS1NOS2ALDH1A1RAB9A | |
| SCHEMBL1942608 | 0.82 | CPS1 (0.70) | KDM2BCPS1MEN1KMT2A | |
| SCHEMBL30514010 | 0.82 | CPS1 (0.70) | KDM2BCPS1MEN1KMT2A | |
| SCHEMBL4839335 | 0.81 | KDM2B (0.50) | KDM2BCPS1ALDH1A1RAB9ANPC1 | |
| SCHEMBL14477305 | 0.81 | KDM2B (0.50) | KDM2BCPS1ALDH1A1RAB9ANPC1 | |
| SCHEMBL7423445 | 0.81 | KDM2B (0.50) | KDM2BCPS1ALDH1A1RAB9ANPC1 | |
| SCHEMBL4113759 | 0.81 | MAPT (0.61) | KDM2BCPS1ALDH1A1RAB9AKDM4E | |
| SCHEMBL4115692 | 0.81 | KDM2B (0.47) | KDM2BCPS1ALDH1A1RAB9ANPC1 | |
| SCHEMBL3909614 | 0.80 | KMT2A (0.47) | KDM2BALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL16163091 | 0.79 | POLB (0.61) | KDM2BCPS1ALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135417-A1 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-11-29 | — | — | WO | disclosed |
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |