Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | APEX1 | P27695 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16695966 | 0.83 | KDM4E (0.47) | ALDH1A1SMN1; SMN2GSK3AGSK3BMEN1 | |
| SCHEMBL3970588 | 0.77 | GSK3A (0.47) | ALDH1A1SMN1; SMN2GSK3AGSK3BMAPK1 | |
| SCHEMBL3547671 | 0.76 | ATM (0.46) | ALDH1A1SMN1; SMN2GSK3AGSK3BMEN1 | |
| SCHEMBL65301 | 0.73 | MAPT (0.54) | ALDH1A1SMN1; SMN2GSK3AGSK3BMAPK1 | |
| SCHEMBL645648 | 0.73 | POLB (0.68) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL680769 | 0.71 | ALDH1A1 (0.57) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL19429544 | 0.71 | NPC1 (0.43) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL5759510 | 0.70 | KDM4E (0.45) | ALDH1A1SMN1; SMN2GSK3AGSK3BMAPK1 | |
| SCHEMBL20861880 | 0.69 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2ALMNAPOLB | |
| SCHEMBL19429625 | 0.69 | KMT2A (0.40) | ALDH1A1SMN1; SMN2GSK3AGSK3BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2017172596-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION (US) | 2017-10-05 | — | — | WO | disclosed |