Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.44 |
| ▸ | RHEB | Q15382 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.36 |
| ▸ | PGR | P06401 | 3/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25267 | 0.81 | MTNR1A (0.62) | MTNR1AMTNR1BRHEBHDAC3HDAC1 | |
| SCHEMBL24451623 | 0.80 | MTNR1A (0.45) | MTNR1AMTNR1BRHEBPARP1MEN1 | |
| SCHEMBL12475578 | 0.80 | HTR1A (0.48) | RHEBHDAC3HDAC1MEN1NPC1 | |
| SCHEMBL24459343 | 0.79 | MTNR1A (0.45) | MTNR1AMTNR1BRHEBPARP1MEN1 | |
| SCHEMBL10377783 | 0.78 | MTNR1A (0.42) | MTNR1AMTNR1BRHEBPARP1MEN1 | |
| SCHEMBL20097158 | 0.78 | RHEB (0.56) | MTNR1AMTNR1BRHEBABCB11HTR1A | |
| SCHEMBL15077049 | 0.77 | MEN1 (0.38) | MTNR1AMTNR1BRHEBHDAC3HDAC1 | |
| SCHEMBL30304098 | 0.74 | KDM4E (0.49) | HDAC3HDAC1MEN1NPC1RAB9A | |
| SCHEMBL17345632 | 0.74 | DAO (0.49) | MTNR1AMTNR1BRHEBPARP1FLT3 | |
| SCHEMBL5768529 | 0.74 | SRD5A2 (0.61) | MTNR1AMTNR1BRHEBHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794611-B1 | PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS | GILEAD SCIENCES INC (US) | 2017-10-11 | — | — | EP | disclosed |