Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 8/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.43 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.41 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19449220 | 0.87 | MT-CO1 (0.47) | SMN1; SMN2ALDH1A1RAB9AMAPTHTT | |
| SCHEMBL19449247 | 0.85 | MT-CO1 (0.61) | SMN1; SMN2ALDH1A1RAB9AMAPTHTT | |
| SCHEMBL17985743 | 0.83 | PAX8 (0.60) | SMN1; SMN2ALDH1A1RAB9AMAPTHTT | |
| SCHEMBL29365433 | 0.83 | PAX8 (0.60) | SMN1; SMN2ALDH1A1RAB9AMAPTHTT | |
| Hydrochloric Acid SCHEMBL29441952 | 0.82 | PAX8 (0.59) | SMN1; SMN2ALDH1A1RAB9AMAPTHTT | |
| Hydrochloric Acid SCHEMBL18632047 | 0.82 | PAX8 (0.59) | SMN1; SMN2ALDH1A1RAB9AMAPTHTT | |
| SCHEMBL31237816 | 0.79 | RAB9A (0.51) | SMN1; SMN2ALDH1A1RAB9AMAPTHTT | |
| SCHEMBL19449221 | 0.75 | MT-CO1 (0.67) | SMN1; SMN2ALDH1A1RAB9AMAPTHTT | |
| SCHEMBL19449283 | 0.73 | ALDH1A1 (0.65) | SMN1; SMN2ALDH1A1RAB9AMAPTHTT | |
| SCHEMBL19449250 | 0.71 | KDM5A (0.56) | SMN1; SMN2ALDH1A1RAB9AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11253517-B2 | Small molecule regulators of steroid receptor coactivators and methods of use thereof | BAYLOR COLLEGE OF MEDICINE (US) | 2022-02-22 | — | — | US | disclosed |
| US-20200085824-A1 | SMALL MOLECULE REGULATORS OF STEROID RECEPTOR COACTIVATORS AND METHODS OF USE THEREOF | BAYLOR COLLEGE OF MEDICINE (US) | 2020-03-19 | — | — | US | disclosed |
| US-20190216810-A1 | SMALL MOLECULE REGULATORS OF STEROID RECEPTOR COACTIVATORS AND METHODS OF USE THEREOF | BAYLOR COLLEGE OF MEDICINE (US) | 2019-07-18 | — | — | US | disclosed |
| US-10265315-B2 | Small molecule regulators of steroid receptor coactivators and methods of use thereof | BAYLOR COLLEGE OF MEDICINE (US) | 2019-04-23 | — | — | US | disclosed |
| US-20170290830-A1 | SMALL MOLECULE REGULATORS OF STEROID RECEPTOR COACTIVATORS AND METHODS OF USE THEREOF | BAYLOR COLLEGE OF MEDICINE (US) | 2017-10-12 | — | — | US | disclosed |
| US-20170290830-A1 | SMALL MOLECULE REGULATORS OF STEROID RECEPTOR COACTIVATORS AND METHODS OF USE THEREOF | BAYLOR COLLEGE OF MEDICINE (US) | 2017-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11253517-B2 | Small molecule regulators of steroid receptor coactivators and methods of use thereof | NCOA2, NCOA3, NCOA1 | SMN1; SMN2 2764/4885ALDH1A1 4490/4885RAB9A 3522/4885 |
| US-20190216810-A1 | SMALL MOLECULE REGULATORS OF STEROID RECEPTOR COACTIVATORS AND METHODS OF USE THEREOF | NCOA2, NCOA3, NCOA1 | SMN1; SMN2 2764/4885ALDH1A1 4490/4885RAB9A 3522/4885 |
| US-20200085824-A1 | SMALL MOLECULE REGULATORS OF STEROID RECEPTOR COACTIVATORS AND METHODS OF USE THEREOF | NCOA2, NCOA3, NCOA1 | SMN1; SMN2 2764/4885ALDH1A1 4490/4885RAB9A 3522/4885 |
| US-10265315-B2 | Small molecule regulators of steroid receptor coactivators and methods of use thereof | NCOA2, NCOA3, NCOA1 | SMN1; SMN2 2764/4885ALDH1A1 4490/4885RAB9A 3522/4885 |
| US-20170290830-A1 | SMALL MOLECULE REGULATORS OF STEROID RECEPTOR COACTIVATORS AND METHODS OF USE THEREOF | NCOA2, NCOA3, NCOA1 | SMN1; SMN2 2764/4885ALDH1A1 4490/4885RAB9A 3522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.