Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | F12 | P00748 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.41 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15947640 | 0.83 | PLAU (0.54) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL2418686 | 0.79 | CYP2A6 (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL29358794 | 0.79 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL251028 | 0.79 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL2852412 | 0.79 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL7544045 | 0.79 | PLAU (0.50) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL2008309 | 0.78 | CLK1 (0.41) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL2013043 | 0.76 | HTT (0.41) | ALDH1A1LMNACYP3A4MAPK1CYP2C19 | |
| SCHEMBL15940603 | 0.75 | ADORA2A (0.54) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL2007551 | 0.73 | LMNA (0.52) | MAPTALDH1A1SMN1; SMN2LMNACOMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 650 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586170-B | Indolinyl acyl derivative and synthetic method of isoquinoline formyl derivative | 江苏集萃分子工程研究院有限公司 | 2024-04-09 | — | — | CN | claimed |
| CN-117586170-A | Indolinyl acyl derivative and synthetic method of isoquinoline formyl derivative | 江苏集萃分子工程研究院有限公司 | 2024-02-23 | — | — | CN | claimed |
| CN-117209395-A | Synthesis method and anticancer activity of selective targeted proliferation cell nuclear antigen drug | 苏州祥沁医疗科技有限公司 | 2023-12-12 | — | — | CN | claimed |
| US-7994335-B2 | Electronically tuned ligands for asymmetric hydrogenation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-09 | — | — | US | claimed |
| US-20100041898-A1 | Electronically Tuned Ligands For Asymmetric Hydrogenation | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-18 | — | — | US | claimed |
| US-20090300800-A1 | D-Amino Acid a Selectable Marker for Barley (Hordeum Vulgare L.) Transformation | BASF PLANT SCIENCE GMBH (DE) | 2009-12-03 | — | — | US | claimed |
| US-20080194605-A1 | (1H-Ind0l-7-Yl)-(Pyrimidin-2-Ylamino)Methanone Derivatives and Related Compounds as Igf-R1 Inhibitors for the Treatment of Cancer | MERCK PATENT GMBH (DE) | 2008-08-14 | — | — | US | claimed |
| WO-2008067218-A1 | ELECTRONICALLY TUNED LIGANDS FOR ASYMMETRIC HYDROGENATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-06-05 | — | — | WO | claimed |
| US-20070248996-A1 | Modulators of beta-amyloid peptide aggregation comprising D-amino acids | PARAECIS PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | US | claimed |
| US-20060014696-A1 | Modulators of beta-amyloid peptide aggregation comprising D-amino acids | PRAECIS PHARMACEUTICALS, INC. (US) | 2006-01-19 | — | — | US | claimed |
| US-5510487-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | claimed |
| US-5482947-A | ENZYME INHIBITORS FOR HIV PROTEASE INHIBITION FROM UREA OR THIOUREA COMPOUNDS | TALLEY JOHN J (US) | 1996-01-09 | — | — | US | claimed |
| US-5430041-A | Amino acid derivatives having antiviral activity | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | claimed |
| US-5322842-A | Tricyclic benzodiazepine derivates, their preparation, and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-21 | — | — | US | claimed |
| EP-0594540-A1 | Antiretroviral acyl compounds | CIBA-GEIGY AG (CH) | 1994-04-27 | — | — | EP | claimed |
| EP-0544909-A1 | TRICYCLIC BENZODIAZEPINE DERIVATES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-09 | — | — | EP | claimed |
| WO-1992003438-A1 | TRICYCLIC BENZODIAZEPINE DERIVATES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-05 | — | — | WO | claimed |
| US-5021421-A | Psychotropic agents | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1991-06-04 | — | — | US | claimed |
| US-4727060-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1988-02-23 | — | — | US | claimed |
| EP-0184550-A2 | 5-Amino-4-hydroxy valeryl amide derivatives | CIBA-GEIGY AG (CH) | 1986-06-11 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070248996-A1 | Modulators of beta-amyloid peptide aggregation comprising D-amino acids | APP, IAPP, BACE1 | PLAU 1700/4885CYP2A6 3217/4885F12 1313/4885 |
| US-20100041898-A1 | Electronically Tuned Ligands For Asymmetric Hydrogenation | BID, HDHD5, HRH4 | PLAU 3052/4885CYP2A6 1228/4885F12 4856/4885 |
| US-20060014696-A1 | Modulators of beta-amyloid peptide aggregation comprising D-amino acids | APP, IAPP, BACE1 | PLAU 1700/4885CYP2A6 3217/4885F12 1313/4885 |
| US-20080194605-A1 | (1H-Ind0l-7-Yl)-(Pyrimidin-2-Ylamino)Methanone Derivatives and Related Compounds as Igf-R1 Inhibitors for the Treatment of Cancer | IGF1R, INHA, CCNO | PLAU 4021/4885CYP2A6 1158/4885F12 360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.