Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 9/20 | 0.61 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.59 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.59 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.59 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.59 |
| ▸ | TGM2 | P21980 | 4/20 | 0.58 |
| ▸ | F13A1 | P00488 | 1/20 | 0.51 |
| ▸ | TGM1 | P22735 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19457356 | 0.90 | SMN1; SMN2 (0.54) | NAMPTABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL19457350 | 0.86 | TGM2 (0.56) | NAMPTABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL19457348 | 0.86 | TGM2 (0.77) | TGM2F13A1TGM1ALDH1A1MAPT | |
| SCHEMBL20885061 | 0.83 | NAMPT (0.64) | NAMPTTGM2F13A1TGM1 | |
| SCHEMBL20885062 | 0.83 | TGM2 (0.55) | NAMPTTGM2F13A1TGM1SMN1; SMN2 | |
| SCHEMBL28177667 | 0.82 | ABCC9 (0.63) | NAMPTABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL11664189 | 0.78 | ABCC9 (0.59) | NAMPTABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7894169 | 0.78 | TGM2 (0.66) | TGM2F13A1TGM1MAPTLMNA | |
| SCHEMBL20885055 | 0.78 | SMN1; SMN2 (0.49) | NAMPTTGM2F13A1TGM1ALDH1A1 | |
| SCHEMBL20885070 | 0.78 | LMNA (0.56) | NAMPTTGM2ALDH1A1MAPTCRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440084-B1 | PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING PI3K-MEDIATED DISORDERS | DANA FARBER CANCER INST INC (US) | 2022-12-21 | — | — | EP | disclosed |
| WO-2017177092-A1 | PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING PI3K-MEDIATED DISORDERS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-10-12 | — | — | WO | disclosed |