Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.58 |
| ▸ | DPP4 | P27487 | 3/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19465583 | 0.80 | CFTR (0.55) | CFTRGRM1KDM4EMAPTMEN1 | |
| SCHEMBL19465591 | 0.75 | KDM4E (0.53) | CFTRKDM4EMAPTALDH1A1KMT2A | |
| SCHEMBL18692830 | 0.75 | CFTR (1.00) | CFTRALDH1A1 | |
| SCHEMBL19465578 | 0.71 | KDM4E (0.60) | CFTRKDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL6281507 | 0.71 | KDM4E (0.58) | DPP4GRM1KDM4EMAPTMEN1 | |
| SCHEMBL2377166 | 0.71 | ALDH1A1 (0.73) | KDM4EMAPTALDH1A1RAB9AGRM2 | |
| SCHEMBL31547886 | 0.70 | GRM1 (0.68) | DPP4GRM1NPC1ALDH1A1HPGD | |
| SCHEMBL13343675 | 0.69 | PTGS2 (0.67) | MAPTMEN1ALDH1A1KMT2AHPGD | |
| SCHEMBL4300658 | 0.69 | MAPK1 (0.54) | MAPTNPC1ALDH1A1RAB9AHPGD | |
| SCHEMBL6287500 | 0.69 | KDM4E (0.59) | DPP4GRM1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796711-B2 | Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and method of use | ABBVIE S.Á.R.L. (LU) | 2017-10-24 | — | — | US | disclosed |