Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8715929 | 0.78 | TSHR (0.46) | CA1CA2TSHRMAPTALDH1A1 | |
| SCHEMBL14287217 | 0.76 | CASP1 (0.48) | CA1CA2TSHRKDM4EMAPT | |
| SCHEMBL29650713 | 0.76 | ALOX15 (0.48) | CA1CA2TSHRMAPTALDH1A1 | |
| SCHEMBL16049999 | 0.76 | ALOX15 (0.48) | CA1CA2TSHRMAPTALDH1A1 | |
| SCHEMBL28522838 | 0.74 | ALOX15 (0.46) | CA1CA2TSHRMAPTALDH1A1 | |
| SCHEMBL3781684 | 0.74 | CA14 (0.48) | CA1CA2KDM4EALDH1A1PLAU | |
| SCHEMBL28939320 | 0.74 | ENPP2 (0.46) | CA1CA2TSHRKDM4EALDH1A1 | |
| SCHEMBL31589865 | 0.74 | ALOX15 (0.54) | CA1CA2TSHRKDM4EMAPT | |
| SCHEMBL9848214 | 0.74 | CA1 (0.42) | CA1CA2TSHRALDH1A1MEN1 | |
| SCHEMBL3784363 | 0.74 | ALOX15 (0.54) | CA1CA2TSHRKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190127368-A1 | NLRP3 MODULATORS | IFM THERAPEUTICS INC (US) | 2019-05-02 | — | — | US | disclosed |
| WO-2017184735-A1 | NLRP3 MODULATORS | IFM THERAPEUTICS, INC (US) | 2017-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190127368-A1 | NLRP3 MODULATORS | NLRP3, TLR7, TLR8 | CA1 4129/4885CA2 3170/4885TSHR 3174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.