Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 2/20 | 0.49 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 5/20 | 0.47 |
| ▸ | CDK7 | P50613 | 2/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.45 |
| ▸ | MAPK6 | Q16659 | 6/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19477350 | 1.00 | PAK4 (0.49) | PAK4PAK1CDK9CDK7PIK3C3 | |
| SCHEMBL25607003 | 0.80 | GPR39 (0.56) | PAK4PAK1PIK3C3HRH4CCNB2 | |
| SCHEMBL27109893 | 0.79 | GPR39 (0.58) | PIK3C3HRH4CCNB2CDK1CCNB1 | |
| SCHEMBL19477097 | 0.77 | HRH3 (0.56) | HRH4CDK1CCNB1MAPK8CDK2 | |
| SCHEMBL31456684 | 0.76 | KDM4E (0.55) | PAK4PAK1CDK9CDK7HRH4 | |
| SCHEMBL25607007 | 0.73 | GPR39 (0.41) | PAK4PAK1PIK3C3HRH4CDK1 | |
| SCHEMBL24065221 | 0.73 | CDK1 (0.54) | PAK4PAK1CDK9CDK7PIK3C3 | |
| SCHEMBL18677322 | 0.73 | CDK1 (0.54) | PAK4PAK1CDK9CDK7PIK3C3 | |
| SCHEMBL6463619 | 0.72 | PAK4 (0.50) | PAK4PAK1CDK9CDK7PIK3C3 | |
| SCHEMBL6457779 | 0.72 | PAK4 (0.50) | PAK4PAK1CDK9CDK7PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017181177-A1 | AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS | Epizyme, Inc. (US) | 2017-10-19 | — | — | WO | disclosed |