Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR39 | O43194 | 2/20 | 0.56 |
| ▸ | CTSK | P43235 | 2/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 4/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.50 |
| ▸ | CDK4 | P11802 | 3/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.50 |
| ▸ | CCND1 | P24385 | 3/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.50 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27109893 | 0.98 | GPR39 (0.58) | GPR39CTSKHRH4KDM4EGAA | |
| SCHEMBL19477097 | 0.86 | HRH3 (0.56) | GPR39HRH4MAPK8CDK1CCNB1 | |
| SCHEMBL19477096 | 0.84 | BRD4 (0.47) | HRH4CDK2CCNE1 | |
| SCHEMBL19477384 | 0.80 | PAK4 (0.49) | GPR39HRH4MAPK8CDK1CCNB1 | |
| SCHEMBL19477350 | 0.80 | PAK4 (0.49) | GPR39HRH4MAPK8CDK1CCNB1 | |
| SCHEMBL3451468 | 0.79 | CTSK (0.58) | CTSKHRH4KDM4EGAAMAPK8 | |
| SCHEMBL91478 | 0.79 | CTSK (0.58) | CTSKHRH4KDM4EGAAMAPK8 | |
| SCHEMBL25607007 | 0.79 | GPR39 (0.41) | GPR39CTSKHRH4MAPK8CDK1 | |
| SCHEMBL91484 | 0.78 | CTSK (0.60) | CTSKHRH4KDM4EGAAMAPK8 | |
| SCHEMBL1033751 | 0.78 | CTSK (0.60) | CTSKHRH4KDM4EGAAMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442947-B1 | AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS | EPIZYME INC (US) | 2023-06-07 | — | — | EP | disclosed |