Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 8/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14983664 | 0.83 | CNR1 (0.38) | KDM4EALDH1A1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL8708374 | 0.80 | P2RX7 (0.42) | P2RX7KDM4EALDH1A1SMN1; SMN2GAA | |
| SCHEMBL14983663 | 0.79 | POLB (0.40) | SORT1POLB | |
| SCHEMBL18179064 | 0.76 | SMN1; SMN2 (0.40) | KDM4EALDH1A1SMN1; SMN2GAASORT1 | |
| SCHEMBL31538477 | 0.76 | P2RX7 (0.59) | P2RX7KDM4EALDH1A1SMN1; SMN2GAA | |
| SCHEMBL2790057 | 0.76 | HPGD (0.39) | KDM4EALDH1A1SMN1; SMN2KMT2ASORT1 | |
| SCHEMBL19485123 | 0.76 | NPSR1 (0.40) | KDM4EALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL13727933 | 0.70 | GAA (0.40) | P2RX7KDM4EALDH1A1SMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL14843114 | 0.69 | KDM4E (0.44) | P2RX7KDM4EALDH1A1SMN1; SMN2GAA | |
| Trifluoroacetic Acid SCHEMBL28190465 | 0.69 | SORT1 (0.40) | KDM4EKMT2AL3MBTL1SORT1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170298055-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298055-A1 | sGC STIMULATORS | GUCY1B1, GUCY1A1, PRKG2 | P2RX7 375/4885KDM4E 1724/4885ALDH1A1 1921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.