SCHEMBL19492

SCHEMBL19492

COC(=O)C(F)C(=O)OC

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.48
CA14 Q9ULX7 2/20 0.40
ALDH1A1 P00352 3/20 0.39
KMT2A Q03164 2/20 0.37
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
TSHR P16473 3/20 0.33
KEAP1 Q14145 1/20 0.33
NFE2L2 Q16236 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33
ZDHHC7 Q9NXF8 1/20 0.33
MGAM O43451 2/20 0.30
GAA P10253 2/20 0.30
SI P14410 2/20 0.30
MGAM2 Q2M2H8 2/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL353238 0.85
SCHEMBL224303 0.85
SCHEMBL25906951 0.84 TSHR (0.40) SMN1; SMN2CA14ALDH1A1KMT2ACA12
SCHEMBL15004183 0.83
SCHEMBL197339 0.83 SMN1; SMN2 (0.40) SMN1; SMN2CA14ALDH1A1KMT2ACA12
SCHEMBL22710491 0.83 SMN1; SMN2 (0.36) SMN1; SMN2CA14
SCHEMBL15704457 0.83 SMN1; SMN2 (0.36) SMN1; SMN2CA14
SCHEMBL23028852 0.81 SMN1; SMN2 (0.39) SMN1; SMN2CA14ALDH1A1KMT2ACA12
Potassium Ion SCHEMBL31028794 0.81 SMN1; SMN2 (0.39) SMN1; SMN2CA14ALDH1A1KMT2ACA12
SCHEMBL7638966 0.81 SMN1; SMN2 (0.41) SMN1; SMN2CA14ALDH1A1KMT2ACA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 321 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119882351-A High-adhesion positive KrF photoresist resin composition 万华化学集团股份有限公司 2025-04-25 CN claimed
CN-118186152-A Multifunctional high-absorption chrome tanning auxiliary agent containing barbituric acid structure and preparation method thereof 南京工业大学 2024-06-14 CN claimed
CN-111635312-B Synthesis method of (E) -2-fluoroalkyl-3-butenoate compound 安阳师范学院 2023-02-21 CN claimed
CN-111138462-B Preparation method and application of 2-fluoro-malonic acid lithium difluoroborate 江苏国泰超威新材料有限公司 2022-10-21 CN claimed
CN-109824512-B Preparation method of 2-fluoro dimethyl malonate 国药集团化学试剂有限公司 2021-06-08 CN claimed
CN-111635312-A Synthesis method of (E) -2-fluoroalkyl-3-butenoate compound 安阳师范学院 2020-09-08 CN claimed
CN-111138462-A Preparation method and application of lithium 2-fluoro-malonate difluoroborate 江苏国泰超威新材料有限公司 2020-05-12 CN claimed
CN-110963955-A Synthesis method of monofluoro spiro compound and intermediate thereof 南京富润凯德生物医药有限公司 2020-04-07 CN claimed
CN-110627718-A Synthesis method of (E) -beta-monofluoroalkyl-beta, gamma-unsaturated amide 安阳师范学院 2019-12-31 CN claimed
EP-0249867-B1 SUBSTITUTED PHENYL ESTERS OF ALPHA-FLUOROACRYLIC ACID HOECHST AKTIENGESELLSCHAFT (DE) 1992-01-02 EP claimed
EP-0203462-B1 ALPHA-FLUOROACRYLIC-ACID ESTERS AND THEIR POLYMERS HOECHST AKTIENGESELLSCHAFT (DE) 1990-08-01 EP claimed
EP-0249867-A2 Substituted phenyl esters of alpha-fluoroacrylic acid HOECHST AKTIENGESELLSCHAFT (DE) 1987-12-23 EP claimed
EP-0203462-A2 Alpha-fluoroacrylic-acid esters and their polymers HOECHST AKTIENGESELLSCHAFT (DE) 1986-12-03 EP claimed
US-12617802-B2 Sulfonimidamide compounds as NLRP3 modulators GENENTECH, INC. (US) 2026-05-05 US disclosed
US-20260109714-A1 PYRIMIDINE-FUSED RING COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF GENFLEET THERAPEUTICS SHANGHAI INC (CN) 2026-04-23 US disclosed
US-20250346613-A1 BORIC ACID PROTEASOME INHIBITOR AND USE THEREOF ARTIVILA BIOPHARMA (CN) 2025-11-13 US disclosed
EP-0334966-A1 PROCESS FOR SYNTHESIZING OPTICALLY ACTIVE COMPOUNDS NGK INSULATORS, LTD. (JP) 1989-10-04 EP disclosed
EP-0249867-A2 Substituted phenyl esters of alpha-fluoroacrylic acid HOECHST AKTIENGESELLSCHAFT (DE) 1987-12-23 EP disclosed
EP-0203462-A2 Alpha-fluoroacrylic-acid esters and their polymers HOECHST AKTIENGESELLSCHAFT (DE) 1986-12-03 EP disclosed
EP-0052339-A1 Fluorobarbituric acid derivatives and their preparation Daikin Kogyo Co., Ltd. (JP) 1982-05-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250346613-A1 BORIC ACID PROTEASOME INHIBITOR AND USE THEREOF PSMA1, PSMB11, PSMB1 SMN1; SMN2 1449/4885CA14 3144/4885ALDH1A1 2948/4885
US-20260109714-A1 PYRIMIDINE-FUSED RING COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF KRAS, NRAS, HRAS SMN1; SMN2 4243/4885CA14 1586/4885ALDH1A1 1260/4885
US-12617802-B2 Sulfonimidamide compounds as NLRP3 modulators NLRP3, NLRP1, PYCARD SMN1; SMN2 2586/4885CA14 3490/4885ALDH1A1 2022/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.