Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 11/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494401 | 0.77 | CFTR (0.46) | ALDH1A1MEN1KMT2AMAPTCHEK1 | |
| SCHEMBL16337192 | 0.76 | KMT2A (0.57) | MAPK8ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL19494695 | 0.75 | MAPK1 (0.41) | ALDH1A1MEN1KMT2AMAPTCHEK1 | |
| SCHEMBL19494892 | 0.74 | MMP1 (0.41) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL19494386 | 0.74 | CFTR (0.39) | ALDH1A1MEN1KMT2AMAPTCHEK1 | |
| SCHEMBL6997948 | 0.69 | JAK2 (0.64) | MAPK8MEN1KMT2AMAPTKDM4E | |
| SCHEMBL19494611 | 0.69 | CFTR (0.45) | ALDH1A1MEN1KMT2AMAPTCHEK1 | |
| SCHEMBL19494312 | 0.68 | MEN1 (0.32) | MEN1KMT2AMAPTKDM4ECFTR | |
| SCHEMBL19494896 | 0.67 | CFTR (0.43) | MAPK8MEN1KMT2ACHEK1CFTR | |
| SCHEMBL19494313 | 0.67 | IKBKB (0.32) | ALDH1A1MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |