Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 4/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19494932 | 0.80 | IKBKB (0.43) | IKBKBJAK2KMT2AMEN1EIF2AK2 | |
| SCHEMBL19494507 | 0.77 | IKBKB (0.40) | IKBKBJAK2KMT2AMEN1EIF2AK2 | |
| SCHEMBL19494765 | 0.69 | CFTR (0.54) | IKBKBJAK2KMT2AMEN1EIF2AK2 | |
| SCHEMBL19494736 | 0.68 | JAK2 (0.32) | IKBKBJAK2KMT2AMEN1NPC1 | |
| SCHEMBL19494388 | 0.68 | MEN1 (0.36) | NNMTIKBKBKMT2AMEN1NPC1 | |
| SCHEMBL19494654 | 0.64 | NNMT (0.35) | NNMTIKBKBJAK2KMT2AMEN1 | |
| SCHEMBL16263935 | 0.64 | JAK2 (0.42) | IKBKBJAK2KMT2AMEN1EIF2AK2 | |
| SCHEMBL19494741 | 0.63 | CFTR (0.49) | IKBKBJAK2KMT2AMEN1EIF2AK2 | |
| SCHEMBL19494397 | 0.63 | CFTR (0.44) | IKBKBJAK2KMT2AMEN1EIF2AK2 | |
| SCHEMBL19494898 | 0.62 | JAK2 (0.45) | IKBKBJAK2KMT2AMEN1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2017-10-25 | — | — | EP | disclosed |