Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.39 |
| ▸ | LPL | P06858 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.34 |
| ▸ | WHR1 | P49842 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | VDR | P11473 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19502159 | 0.92 | LIPG (0.39) | LIPGLPLEGFRMEN1KMT2A | |
| SCHEMBL19502155 | 0.90 | LPL (0.37) | LIPGLPLEGFRMEN1KMT2A | |
| SCHEMBL22195877 | 0.89 | LPL (0.38) | LIPGLPLEGFRMEN1KMT2A | |
| SCHEMBL29637773 | 0.88 | LIPG (0.44) | LIPGLPLEGFRMEN1KMT2A | |
| SCHEMBL19501987 | 0.88 | LIPG (0.44) | LIPGLPLEGFRMEN1KMT2A | |
| SCHEMBL19502384 | 0.88 | LIPG (0.39) | LIPGLPLEGFRMEN1KMT2A | |
| SCHEMBL19502230 | 0.87 | LIPG (0.43) | LIPGLPLEGFRMEN1KMT2A | |
| SCHEMBL20983882 | 0.86 | LIPG (0.48) | LIPGLPLEGFRPRMT5WDR77 | |
| SCHEMBL21999344 | 0.86 | LIPG (0.45) | LIPGLPLEGFRPRMT5WDR77 | |
| SCHEMBL38266197 | 0.86 | LIPG (0.48) | LIPGLPLEGFRPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190165282-A1 | HETEROCYCLIC COMPOUNDS COMPRISING DIBENZOFURAN AND/OR DIBENZOTHIOPHENE STRUCTURES | MERCK PATENT GMBH (DE) | 2019-05-30 | — | — | US | disclosed |
| WO-2017178311-A1 | HETEROCYCLIC COMPOUNDS COMPRISING DIBENZOFURAN AND/OR DIBENZOTHIOPHENE STRUCTURES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190165282-A1 | HETEROCYCLIC COMPOUNDS COMPRISING DIBENZOFURAN AND/OR DIBENZOTHIOPHENE STRUCTURES | DDT, NUDT1, ETFB | LIPG 4625/4885LPL 4781/4885EGFR 2418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.