Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | DUT | P33316 | 3/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
| ▸ | PGK2 | P07205 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19474691 | 1.00 | KIF11 (0.43) | KIF11PTPN1CYP2C19HIF1AALDH1A1 | |
| SCHEMBL19504244 | 0.82 | KIF11 (0.43) | KIF11PTPN1CYP2C19HIF1AALDH1A1 | |
| SCHEMBL19469823 | 0.81 | KIF11 (0.46) | KIF11PTPN1CYP2C19ALDH1A1ALOX15 | |
| SCHEMBL30124105 | 0.77 | KIF11 (0.48) | KIF11PTPN1CYP2C19HIF1AALDH1A1 | |
| SCHEMBL5872334 | 0.77 | KIF11 (0.52) | KIF11PTPN1ALDH1A1DUTMAPK1 | |
| SCHEMBL8850056 | 0.77 | KIF11 (0.52) | KIF11CYP2C19HIF1AALDH1A1ALOX15 | |
| SCHEMBL9039468 | 0.76 | KIF11 (0.44) | KIF11CYP2C19HIF1AALDH1A1ALOX15 | |
| SCHEMBL25746320 | 0.75 | SLC6A11 (0.44) | KIF11ALDH1A1ALOX15MAPK1KMT2A | |
| SCHEMBL28021468 | 0.74 | KIF11 (0.42) | KIF11CYP2C19HIF1AALDH1A1ALOX15 | |
| SCHEMBL15895163 | 0.73 | KIF11 (0.44) | KIF11CYP2C19HIF1AALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017182495-A1 | INDAZOLE DERIVATIVES THAT DOWN-REGULATE THE ESTROGEN RECEPTOR AND POSSESS ANTI-CANCER ACTIVITY | ASTRAZENECA AB (SE) | 2017-10-26 | — | — | WO | disclosed |