Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.58 |
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.52 |
| ▸ | PARP1 | P09874 | 6/20 | 0.52 |
| ▸ | F7 | P08709 | 1/20 | 0.52 |
| ▸ | F3 | P13726 | 1/20 | 0.52 |
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1951410 | 0.89 | PARP11 (0.63) | MAOAPARP10PARP1PARP11PDPK1 | |
| SCHEMBL1952863 | 0.87 | PARP10 (0.65) | MAOAPARP10PARP1F7F3 | |
| SCHEMBL2640511 | 0.86 | MAOA (0.45) | MAOAPARP10PARP1F7F3 | |
| SCHEMBL18668933 | 0.82 | PARP10 (0.57) | PARP10PARP1F7F3PARP11 | |
| SCHEMBL6131245 | 0.77 | MAOA (0.46) | MAOANTRK1MAOBHSD17B3 | |
| SCHEMBL3008897 | 0.75 | ROCK2 (0.51) | PARP10PARP1F7F3PARP11 | |
| SCHEMBL3008902 | 0.75 | ROCK2 (0.51) | PARP10PARP1F7F3PARP11 | |
| SCHEMBL2027837 | 0.75 | PARP10 (0.63) | PARP10PARP1F7F3PARP11 | |
| SCHEMBL21460002 | 0.74 | PARP10 (0.58) | PARP10PARP1F7F3PARP11 | |
| SCHEMBL11022780 | 0.74 | MAOA (0.55) | MAOADDB1CRBNMAPK1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438044-B1 | COMPOUNDS | JAPAN TOBACCO INC (JP) | 2019-01-23 | — | — | EP | disclosed |
| US-8399481-B2 | Compounds | XENTION LTD (GB) | 2013-03-19 | — | — | US | disclosed |
| EP-2438044-A1 | COMPOUNDS | Xention Limited (GB) | 2012-04-11 | — | — | EP | disclosed |
| US-20110136859-A1 | Compounds | XENTION LTD. (GB) | 2011-06-09 | — | — | US | disclosed |
| WO-2010139953-A1 | COMPOUNDS | XENTION LIMITED (GB) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136859-A1 | Compounds | CYP2C8, CYP3A7, CYP2A7 | MAOA 1502/4885PARP10 2469/4885PARP1 4078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.