Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 7/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.49 |
| ▸ | KDR | P35968 | 7/20 | 0.49 |
| ▸ | FLT1 | P17948 | 5/20 | 0.41 |
| ▸ | FLT4 | P35916 | 5/20 | 0.41 |
| ▸ | PGK1 | P00558 | 4/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20853 | 0.91 | TLR9 (0.48) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL15207403 | 0.87 | NOS3 (0.42) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL15207623 | 0.82 | CALCA (0.39) | FLT3MAPTTLR8POLB | |
| SCHEMBL19506 | 0.79 | FGFR1 (0.53) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL17908146 | 0.78 | ALDH1A1 (0.46) | MAPTTLR7TLR8POLBHPGD | |
| SCHEMBL20177 | 0.73 | KDM4E (0.41) | MAPTTLR7POLBHPGD | |
| SCHEMBL21252510 | 0.71 | FGFR1 (0.49) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL20852 | 0.70 | ALDH1A1 (0.45) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL24403 | 0.69 | JAK2 (0.44) | FGFR1FGFR2FGFR4FGFR3KDR | |
| SCHEMBL26928630 | 0.66 | FGFR1 (1.00) | FGFR1FGFR2FGFR4FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609098-B1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-07-13 | — | — | EP | claimed |