SCHEMBL1951237

SCHEMBL1951237

N#Cc1ccc(-c2c(F)[c]c(F)cc2C(F)(C(F)(F)F)C(F)(F)F)cc1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 3/20 0.43
PTPN5 P54829 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
DGAT1 O75907 1/20 0.33
SOAT1 P35610 1/20 0.33
KCNH2 Q12809 1/20 0.33
TRPA1 O75762 1/20 0.32
SCN5A Q14524 1/20 0.32
SCN9A Q15858 1/20 0.32
PGR P06401 1/20 0.32
MMP3 P08254 1/20 0.32
PDK2 Q15119 1/20 0.32
CYP11B2 P19099 1/20 0.31
GYS1 P13807 1/20 0.30
PSD A5PKW4 1/20 0.30
TRPV4 Q9HBA0 1/20 0.30
CYP19A1 P11511 1/20 0.30
PTGS1 P23219 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1950432 0.85 PTPN5 (0.38) PTPN5PGRPDK2
SCHEMBL1948298 0.76 KIF11 (0.39) KIF11PTPN5HDAC1HDAC6DGAT1
SCHEMBL1946386 0.76 KIF11 (0.39) KIF11PTPN5HDAC1HDAC6DGAT1
SCHEMBL1950349 0.76 KIF11 (0.39) KIF11PTPN5HDAC1HDAC6DGAT1
SCHEMBL1950954 0.76 KIF11 (0.39) KIF11PTPN5HDAC1HDAC6DGAT1
SCHEMBL1948040 0.75 KIF11 (0.41) KIF11PTPN5HDAC1HDAC6DGAT1
SCHEMBL1950429 0.75 AR (0.37) PTPN5TRPA1PGRPDK2
SCHEMBL1949145 0.74 KIF11 (0.38) KIF11PTPN5HDAC1HDAC6DGAT1
SCHEMBL1948959 0.74 KIF11 (0.40) KIF11PTPN5HDAC1HDAC6DGAT1
SCHEMBL1949661 0.74 KIF11 (0.38) KIF11PTPN5HDAC1HDAC6DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9084420-B2 Amide derivative, pest control agent containing the amide derivative, and pest controlling method MITSUI CHEMICALS AGRO, INC. (JP) 2015-07-21 US disclosed
US-20140107368-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND PEST CONTROLLING METHOD MITSUI CHEMICALS AGRO, INC. (JP) 2014-04-17 US disclosed
US-8633228-B2 Amide derivative, pest control agent containing the amide derivative, and pest controlling method MITSUI CHEMICALS AGRO, INC. (JP) 2014-01-21 US disclosed
US-20110136878-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND PEST CONTROLLING METHOD Mitsui Chemicals Agro., Inc. (JP) 2011-06-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110136878-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND PEST CONTROLLING METHOD L3MBTL1, L3MBTL4, L3MBTL3 KIF11 2089/4885PTPN5 1167/4885HDAC1 63/4885
US-20140107368-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND PEST CONTROLLING METHOD L3MBTL1, L3MBTL4, L3MBTL3 KIF11 2089/4885PTPN5 1167/4885HDAC1 63/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.