Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19520375 | 0.92 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL19520353 | 0.90 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL19520585 | 0.90 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL19538744 | 0.87 | LMNA (0.67) | ALDH1A1SMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL17725602 | 0.86 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL19520411 | 0.82 | TSHR (0.66) | ALDH1A1SMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL19549073 | 0.82 | MAPT (0.71) | ALDH1A1SMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL24021621 | 0.81 | TSHR (0.56) | ALDH1A1SMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL19520407 | 0.81 | SMN1; SMN2 (0.63) | ALDH1A1SMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL19538809 | 0.81 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2TSHRHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448853-B1 | COMPOUNDS FOR MODULATING AQUAPORINS | APOGLYX AB (SE) | 2021-11-17 | — | — | EP | claimed |
| US-10730865-B2 | Compounds for modulating aquaporins | APOGLYX AB (SE) | 2020-08-04 | — | — | US | claimed |
| US-20190127360-A1 | COMPOUNDS FOR MODULATING AQUAPORINS | APOGLYX AB (SE) | 2019-05-02 | — | — | US | claimed |
| WO-2017186893-A1 | COMPOUNDS FOR MODULATING AQUAPORINS | APOGLYX AB (SE) | 2017-11-02 | — | — | WO | claimed |
| EP-3448853-B1 | COMPOUNDS FOR MODULATING AQUAPORINS | APOGLYX AB (SE) | 2021-11-17 | — | — | EP | disclosed |
| US-10730865-B2 | Compounds for modulating aquaporins | APOGLYX AB (SE) | 2020-08-04 | — | — | US | disclosed |
| US-10730865-B2 | Compounds for modulating aquaporins | APOGLYX AB (SE) | 2020-08-04 | — | — | US | disclosed |
| US-20190127360-A1 | COMPOUNDS FOR MODULATING AQUAPORINS | APOGLYX AB (SE) | 2019-05-02 | — | — | US | disclosed |
| US-20190127360-A1 | COMPOUNDS FOR MODULATING AQUAPORINS | APOGLYX AB (SE) | 2019-05-02 | — | — | US | disclosed |
| WO-2017186893-A1 | COMPOUNDS FOR MODULATING AQUAPORINS | APOGLYX AB (SE) | 2017-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10730865-B2 | Compounds for modulating aquaporins | AQP1, AQP4, AQP3 | ALDH1A1 1917/4885SMN1; SMN2 4791/4885TSHR 3510/4885 |
| US-20190127360-A1 | COMPOUNDS FOR MODULATING AQUAPORINS | AQP1, AQP4, AQP3 | ALDH1A1 1917/4885SMN1; SMN2 4791/4885TSHR 3510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.