Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 13/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18613031 | 0.86 | ALDH1A1 (0.40) | MAOBMMP2ADAM17ALDH1A1TAS1R3 | |
| SCHEMBL18313716 | 0.83 | TAS1R3 (0.46) | MAOBADORA3MMP2ADAM17CA12 | |
| Hydrochloric Acid SCHEMBL18305551 | 0.81 | TAS1R3 (0.45) | MAOBADORA3MMP2ADAM17CA12 | |
| SCHEMBL18612896 | 0.81 | MAOB (0.44) | MAOBADORA3MMP2ADAM17CA12 | |
| SCHEMBL12248480 | 0.80 | MAOB (0.50) | MAOBADORA3MMP2ADAM17CA12 | |
| SCHEMBL11291790 | 0.79 | CYP2D6 (0.53) | MAOBCA12CA9ALDH1A1TAS1R3 | |
| SCHEMBL9430490 | 0.73 | MAOB (0.49) | MAOBADORA3MMP2ADAM17CA12 | |
| SCHEMBL18305557 | 0.70 | ADAM17 (0.37) | MAOBADORA3MMP2ADAM17CA12 | |
| SCHEMBL18577816 | 0.70 | ADAM17 (0.37) | MAOBADORA3MMP2ADAM17CA12 | |
| SCHEMBL25764440 | 0.70 | MMP2 (0.46) | MAOBADORA3MMP2ADAM17CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9802927-B2 | Oxadiazine compounds and methods of use thereof | DENALI THERAPEUTICS, INC. (US) | 2017-10-31 | — | — | US | disclosed |