Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.54 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19533519 | 0.78 | GLS (0.38) | FGFR1RPS6KA5ALDH1A1MAPTHPGD | |
| SCHEMBL29929291 | 0.76 | MAPT (0.41) | RPS6KA5ALDH1A1HTTMAPTHPGD | |
| SCHEMBL26977540 | 0.76 | MAPT (0.41) | RPS6KA5ALDH1A1HTTMAPTHPGD | |
| SCHEMBL16140670 | 0.76 | RPS6KA5 (0.67) | FGFR1RPS6KA5HTTMKNK2MAPT | |
| SCHEMBL31099427 | 0.74 | FGFR1 (0.75) | FGFR1ALDH1A1HTTMAPTALOX5 | |
| SCHEMBL19544869 | 0.73 | EGFR (0.43) | FGFR1ALDH1A1HTTMKNK2MAPT | |
| SCHEMBL30671840 | 0.71 | CYP19A1 (0.42) | FGFR1ALDH1A1MAPTL3MBTL1KMT2A | |
| SCHEMBL3300702 | 0.71 | FGFR1 (0.70) | FGFR1ALDH1A1HTTMKNK2MAPT | |
| SCHEMBL19911376 | 0.71 | FGFR1 (1.00) | FGFR1ALDH1A1HTTMAPTHPGD | |
| SCHEMBL19624636 | 0.70 | MAPT (0.37) | RPS6KA5ALDH1A1HTTMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662174-B2 | BTK inhibitor | HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC. (CN) | 2020-05-26 | — | — | US | disclosed |
| EP-3246317-A1 | BTK INHIBITOR | Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. (CN) | 2017-11-22 | — | — | EP | disclosed |
| US-20170313683-A1 | BTK INHIBITOR | HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC. (CN) | 2017-11-02 | — | — | US | disclosed |
| US-20170313683-A1 | BTK INHIBITOR | HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC. (CN) | 2017-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662174-B2 | BTK inhibitor | BTK, SYK, LYN | FGFR1 947/4885RPS6KA5 797/4885ALDH1A1 4122/4885 |
| US-20170313683-A1 | BTK INHIBITOR | BTK, SYK, LYN | FGFR1 947/4885RPS6KA5 797/4885ALDH1A1 4122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.