Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21016237 | 0.98 | CYP19A1 (0.60) | CYP19A1HRH4HRH3DPP4MIF | |
| SCHEMBL12432227 | 0.92 | CYP19A1 (0.49) | CYP19A1HRH4HRH3DPP4MIF | |
| SCHEMBL19535202 | 0.86 | CYP19A1 (0.55) | CYP19A1HRH4HRH3DPP4MIF | |
| SCHEMBL19535084 | 0.83 | HRH4 (0.56) | CYP19A1HRH4HRH3DPP4MIF | |
| SCHEMBL21286188 | 0.78 | DPP4 (0.54) | CYP19A1HRH4HRH3DPP4MIF | |
| SCHEMBL26947314 | 0.78 | CYP19A1 (0.55) | CYP19A1HRH4HRH3DPP4MIF | |
| SCHEMBL19535067 | 0.78 | CYP19A1 (0.46) | CYP19A1HRH4HRH3DPP4MIF | |
| SCHEMBL9138481 | 0.77 | CYP19A1 (0.57) | CYP19A1HRH4HRH3DPP4MIF | |
| SCHEMBL9091212 | 0.77 | CYP19A1 (0.57) | CYP19A1HRH4HRH3DPP4MIF | |
| SCHEMBL12851402 | 0.77 | CYP19A1 (0.50) | CYP19A1HRH4HRH3DPP4MIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11242331-B2 | Analogs of yohimbine and uses thereof | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2022-02-08 | — | — | US | disclosed |
| US-11130764-B2 | Analogs of vincamine and uses thereof | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2021-09-28 | — | — | US | disclosed |
| US-20190256490-A1 | ANALOGS OF YOHIMBINE AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2019-08-22 | — | — | US | disclosed |
| WO-2017190038-A1 | ANALOGS OF YOHIMBINE AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2017-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11242331-B2 | Analogs of yohimbine and uses thereof | MAOA, MAOB, NPY5R | CYP19A1 218/4885HRH4 407/4885HRH3 203/4885 |
| US-20190256490-A1 | ANALOGS OF YOHIMBINE AND USES THEREOF | MAOA, MAOB, NPY5R | CYP19A1 218/4885HRH4 407/4885HRH3 203/4885 |
| US-11130764-B2 | Analogs of vincamine and uses thereof | GLS, GLS2, VAT1 | CYP19A1 209/4885HRH4 3431/4885HRH3 2557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.