Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27914509 | 0.88 | EPHX1 (0.48) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL15765934 | 0.88 | EPHX1 (0.48) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL18502917 | 0.86 | EPHX1 (0.47) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL18471329 | 0.85 | USP30 (0.49) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL23931026 | 0.85 | USP30 (0.49) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL23931025 | 0.85 | USP30 (0.49) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL23931084 | 0.85 | USP30 (0.49) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL23931024 | 0.85 | USP30 (0.49) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL2281041 | 0.85 | HPGD (0.48) | EPHX1HPGDRECQLPTPN2PTPN1 | |
| SCHEMBL12490605 | 0.85 | EPHX1 (0.49) | EPHX1HPGDRECQLPTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081523-B1 | SUBSTITUTED BICYCLIC PIPERIDINE DERIVATIVES USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2024-12-25 | — | — | EP | disclosed |
| CN-114901660-B | Substituted bicyclic compounds useful as T cell activators | 百时美施贵宝公司 | 2024-10-15 | — | — | CN | disclosed |
| US-11964973-B2 | Substituted bicyclic compounds useful as T cell activators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-04-23 | — | — | US | disclosed |
| WO-2021133750-A1 | SUBSTITUTED BICYCLIC PIPERIDINE DERIVATIVES USEFUL AS T CELL ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-07-01 | — | — | WO | disclosed |
| US-20210188845-A1 | SUBSTITUTED BICYCLIC COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY | 2021-06-24 | — | — | US | disclosed |
| EP-3448850-B1 | PIPERIDINYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-11-04 | — | — | EP | disclosed |
| US-10428024-B2 | Piperidinyl derivatives | MERCK PATENT GMBH (DE) | 2019-10-01 | — | — | US | disclosed |
| US-20190135753-A1 | PIPERIDINYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-05-09 | — | — | US | disclosed |
| WO-2017186653-A1 | PIPERIDINYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428024-B2 | Piperidinyl derivatives | PDK1, PDK2, PDK3 | EPHX1 2058/4885HPGD 124/4885RECQL 431/4885 |
| US-20190135753-A1 | PIPERIDINYL DERIVATIVES | PDK1, PDK2, PDK3 | EPHX1 2058/4885HPGD 124/4885RECQL 431/4885 |
| US-20210188845-A1 | SUBSTITUTED BICYCLIC COMPOUNDS USEFUL AS T CELL ACTIVATORS | DGKA, DGKZ, DGKK | EPHX1 3760/4885HPGD 4348/4885RECQL 1308/4885 |
| US-11964973-B2 | Substituted bicyclic compounds useful as T cell activators | DGKA, DGKZ, DGKK | EPHX1 3760/4885HPGD 4348/4885RECQL 1308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.