Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19547196 | 0.79 | NTRK1 (0.41) | OPRM1 | |
| SCHEMBL16474295 | 0.68 | RIPK1 (0.34) | RIPK1LMNAOPRK1OPRM1OPRD1 | |
| SCHEMBL20340606 | 0.68 | KDM4E (0.38) | RIPK1LMNAPSEN1PSEN2APH1B | |
| SCHEMBL15037563 | 0.67 | RIPK1 (0.36) | RIPK1 | |
| SCHEMBL19547159 | 0.67 | PSEN1 (0.34) | RIPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL19547156 | 0.67 | PSEN1 (0.34) | RIPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24508692 | 0.67 | RIPK1 (0.52) | RIPK1LMNAOPRK1OPRM1OPRD1 | |
| SCHEMBL19547145 | 0.67 | JAK2 (0.33) | RIPK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28828299 | 0.66 | NTRK1 (0.40) | OPRM1 | |
| SCHEMBL16881533 | 0.65 | OPRK1 (0.33) | RIPK1OPRK1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791139-B1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS | Dr Reddys Laboratories Ltd (IN) | 2017-11-08 | — | — | EP | disclosed |