Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20340606 | 0.79 | KDM4E (0.38) | RIPK1DRD2LMNA | |
| SCHEMBL19275745 | 0.74 | RIPK1 (0.58) | RIPK1LMNAOPRM1OPRD1OPRK1 | |
| SCHEMBL4301475 | 0.73 | RIPK1 (0.43) | RIPK1 | |
| SCHEMBL20349553 | 0.73 | TRPA1 (0.49) | MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL22382687 | 0.72 | JAK2 (0.50) | DRD2 | |
| SCHEMBL18783105 | 0.70 | LMNA (0.56) | RIPK1LMNAOPRM1OPRD1OPRK1 | |
| SCHEMBL16429280 | 0.69 | L3MBTL3 (0.40) | DRD2 | |
| SCHEMBL16959745 | 0.69 | NPY5R (0.30) | — | |
| SCHEMBL23491516 | 0.69 | TRPA1 (0.44) | MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL19547178 | 0.68 | RIPK1 (0.33) | RIPK1LMNAOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350071-B1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2014-01-08 | — | — | EP | disclosed |