Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2759750 | 0.87 | CYP1A2 (0.33) | CYP1A2CYP3A4CYP2C19MEN1MAPK1 | |
| SCHEMBL2759754 | 0.87 | CYP1A2 (0.33) | CYP1A2CYP3A4CYP2C19MEN1MAPK1 | |
| SCHEMBL14998220 | 0.80 | POLB (0.32) | CYP1A2CYP3A4CYP2C19MAPK1POLB | |
| SCHEMBL15300245 | 0.80 | ACACB (0.35) | MEN1KMT2APOLB | |
| SCHEMBL12275427 | 0.80 | MEN1 (0.31) | MEN1MAPK1KMT2APOLB | |
| SCHEMBL1954896 | 0.80 | MEN1 (0.31) | MEN1MAPK1KMT2A | |
| SCHEMBL13288539 | 0.79 | KMT2A (0.36) | CYP1A2CYP3A4CYP2C19KMT2A | |
| SCHEMBL2759778 | 0.79 | FPR2 (0.33) | MEN1MAPK1KMT2A | |
| SCHEMBL11989362 | 0.79 | ACACB (0.46) | CYP1A2CYP3A4CYP2C19POLB | |
| SCHEMBL12460526 | 0.79 | ACACB (0.43) | CYP1A2CYP3A4CYP2C19KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703165-B2 | Spiro fused 1-amino-piperdine pyrrolidine dione derivatives with pesticidal activity | SYNGENTA CROP PROTECTION, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| EP-2507240-B1 | SPIRO FUSED 1-AMINO-PIPERIDINE PYRROLIDINE DIONE DERIVATIVES WITH PESTICIDAL ACTIVITY | SYNGENTA PARTICIPATIONS AG (CH) | 2014-01-15 | — | — | EP | disclosed |
| EP-2507240-A1 | SPIRO FUSED 1 -AMINO - PIPERIDINE PYRROLIDINE DIONE DERIVATIVES WITH PESTICIDAL ACTIVITY | Syngenta Participations AG (CH) | 2012-10-10 | — | — | EP | disclosed |
| US-20120245026-A1 | SPIRO FUSED 1-AMINO - PIPERDINE PYRROLIDINE DIONE DERIVATIVES WITH PESTICIDAL ACTIVITY | SYNGENTA CROP PROTECTION LLC (US) | 2012-09-27 | — | — | US | disclosed |
| US-20120245026-A1 | SPIRO FUSED 1-AMINO - PIPERDINE PYRROLIDINE DIONE DERIVATIVES WITH PESTICIDAL ACTIVITY | SYNGENTA CROP PROTECTION LLC (US) | 2012-09-27 | — | — | US | disclosed |
| US-20120245026-A1 | SPIRO FUSED 1-AMINO - PIPERDINE PYRROLIDINE DIONE DERIVATIVES WITH PESTICIDAL ACTIVITY | SYNGENTA CROP PROTECTION LLC (US) | 2012-09-27 | — | — | US | disclosed |
| WO-2011067135-A1 | SPIRO FUSED 1 -AMINO - PIPERIDINE PYRROLIDINE DIONE DERIVATIVES WITH PESTICIDAL ACTIVITY | SYNGENTA PARTICIPATIONS AG (CH) | 2011-06-09 | — | — | WO | disclosed |
| WO-2011067240-A1 | SPIRO FUSED 1 -AMINO - PIPERIDINE PYRROLIDINE DIONE DERIVATIVES WITH PESTICIDAL ACTIVITY | SYNGENTA PARTICIPATIONS AG (CH) | 2011-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245026-A1 | SPIRO FUSED 1-AMINO - PIPERDINE PYRROLIDINE DIONE DERIVATIVES WITH PESTICIDAL ACTIVITY | DDT, CAT, AQP1 | CYP1A2 212/4885CYP3A4 842/4885CYP2C19 641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.