Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PMM2 | O15305 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9263852 | 0.75 | PHOSPHO1 (0.47) | NPSR1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL28550660 | 0.72 | KAT2B (0.46) | NPSR1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL12632651 | 0.69 | KAT2B (0.61) | NPSR1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL259065 | 0.69 | ALDH1A1 (0.80) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL10877169 | 0.69 | ALDH1A1 (0.80) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL235 | 0.69 | ALDH1A1 (0.80) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| Benzophenone SCHEMBL5162782 | 0.69 | ALDH1A1 (0.80) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9262493 | 0.69 | MAPT (0.46) | NPSR1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL15030108 | 0.68 | ALDH1A1 (0.70) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| Bicarbonate SCHEMBL9817083 | 0.67 | ALDH1A1 (0.76) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518957-B2 | Methanocarba adenosine derivatives, pharmaceutical compositions, and method of reducing intraocular pressure | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120264769-A1 | METHANOCARBA ADENOSINE DERIVATIVES AND DENDRIMER CONJUGATES THEREOF | The United States of Americia, as represented by the Secretary, Department of Health and Human Serv (US) | 2012-10-18 | — | — | US | disclosed |
| EP-2507241-A1 | METHANOCARBA ADENOSINE DERIVATIVES AND DENDRIMER CONJUGATES THEREOF | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068978-A1 | METHANOCARBA ADENOSINE DERIVATIVES AND DENDRIMER CONJUGATES THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264769-A1 | METHANOCARBA ADENOSINE DERIVATIVES AND DENDRIMER CONJUGATES THEREOF | ADORA3, ADORA2A, ADORA1 | NPSR1 766/4885NPC1 1722/4885RAB9A 2033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.