Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19554374 | 0.92 | KDM4E (0.49) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL19554377 | 0.90 | SMN1; SMN2 (0.51) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL19554142 | 0.88 | MAPT (0.49) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL19554220 | 0.87 | KDM4E (0.42) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL19554871 | 0.85 | F10 (0.48) | MEN1KMT2ASMN1; SMN2NPC1AHR | |
| SCHEMBL19554361 | 0.83 | HDAC1 (0.41) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL19555285 | 0.82 | NPC1 (0.45) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL19554101 | 0.81 | CYP1A2 (0.45) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL19575799 | 0.80 | MAPT (0.47) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL19554930 | 0.79 | GPR35 (0.42) | MAPTLMNAMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | claimed |
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | disclosed |
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | disclosed |