Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | ATF4 | P18848 | 6/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555489 | 0.93 | ATF4 (0.40) | CNR1ATF4PPARGPPARA | |
| SCHEMBL19555498 | 0.88 | MAOB (0.39) | ATF4PPARGPPARA | |
| SCHEMBL19569284 | 0.86 | ATF4 (0.46) | CNR1ATF4ATM | |
| SCHEMBL30025580 | 0.86 | ATF4 (0.46) | CNR1ATF4ATM | |
| SCHEMBL19555452 | 0.85 | ATF4 (0.36) | ATF4FFAR1SLC6A4 | |
| SCHEMBL19555508 | 0.84 | ATF4 (0.42) | ATF4PPARGPPARA | |
| SCHEMBL19555478 | 0.83 | ATF4 (0.37) | ATF4FFAR1PPARGPPARA | |
| SCHEMBL22668962 | 0.79 | ATF4 (0.43) | CNR1ATF4ALDH1A1GAAALOX15 | |
| SCHEMBL19569435 | 0.78 | ATF4 (0.54) | ATF4 | |
| SCHEMBL19555488 | 0.76 | ATF4 (0.38) | ATF4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452448-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |