Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 11/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555452 | 0.91 | ATF4 (0.36) | ATF4FFAR1FFAR4HRH1CCR3 | |
| SCHEMBL19555488 | 0.91 | ATF4 (0.38) | ATF4IDO1MAOBHRH1CCR3 | |
| SCHEMBL19555498 | 0.91 | MAOB (0.39) | ATF4PPARGPPARAMAOBHRH1 | |
| SCHEMBL19555508 | 0.85 | ATF4 (0.42) | ATF4PPARGPPARA | |
| SCHEMBL19569442 | 0.84 | ATF4 (0.52) | ATF4MAOB | |
| SCHEMBL30026133 | 0.84 | ATF4 (0.52) | ATF4MAOB | |
| SCHEMBL19555474 | 0.83 | CNR1 (0.34) | ATF4FFAR1PPARGPPARA | |
| SCHEMBL19555489 | 0.80 | ATF4 (0.40) | ATF4PPARGPPARA | |
| SCHEMBL19569214 | 0.78 | ATF4 (0.62) | ATF4 | |
| SCHEMBL19569206 | 0.76 | ATF4 (0.62) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452448-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |