Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.39 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | ATF4 | P18848 | 7/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555478 | 0.91 | ATF4 (0.37) | MAOBATF4PPARGPPARAHRH1 | |
| SCHEMBL19555474 | 0.88 | CNR1 (0.34) | ATF4PPARGPPARA | |
| SCHEMBL19555452 | 0.85 | ATF4 (0.36) | ATF4HRH1CCR3 | |
| SCHEMBL30026044 | 0.85 | ATF4 (0.50) | MAOBMAOAATF4 | |
| SCHEMBL19569211 | 0.85 | ATF4 (0.50) | MAOBMAOAATF4 | |
| SCHEMBL19555489 | 0.84 | ATF4 (0.40) | ATF4PPARGPPARA | |
| SCHEMBL19555488 | 0.83 | ATF4 (0.38) | MAOBATF4HRH1CCR3 | |
| SCHEMBL19555508 | 0.79 | ATF4 (0.42) | ATF4PPARGPPARASCN9A | |
| SCHEMBL19569590 | 0.79 | ATF4 (0.59) | ATF4 | |
| SCHEMBL19555449 | 0.76 | ATF4 (0.53) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452448-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |