Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 5/20 | 0.42 |
| ▸ | BACE1 | P56817 | 5/20 | 0.42 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24093082 | 0.91 | GRIN2B (0.54) | MEN1KMT2ARAB9AGRIN2BACHE | |
| SCHEMBL1547169 | 0.84 | MEN1 (0.96) | MEN1KMT2ARAB9AHRH3HDAC1 | |
| SCHEMBL24092992 | 0.82 | POLB (0.59) | MEN1KMT2ARAB9AHRH3KDM1A | |
| SCHEMBL19567669 | 0.82 | POLB (0.59) | MEN1KMT2ARAB9AHRH3KDM1A | |
| SCHEMBL19568087 | 0.82 | POLB (0.59) | MEN1KMT2ARAB9AHRH3KDM1A | |
| SCHEMBL24093028 | 0.82 | LOXL2 (0.46) | MEN1KMT2ARAB9AHRH3KDM1A | |
| SCHEMBL24093001 | 0.82 | BCHE (0.48) | MEN1KMT2ARAB9AHRH3KDM1A | |
| SCHEMBL23514564 | 0.82 | LOXL2 (0.46) | MEN1KMT2ARAB9AHRH3KDM1A | |
| SCHEMBL19567378 | 0.82 | BCHE (0.48) | MEN1KMT2ARAB9AHRH3KDM1A | |
| SCHEMBL24093150 | 0.81 | SLC6A2 (0.54) | MEN1KMT2ARAB9AGRIN2BKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452464-B1 | PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF | HOFFMANN LA ROCHE (CH) | 2021-12-15 | — | — | EP | disclosed |