Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | ATF4 | P18848 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569440 | 0.94 | ATF4 (0.52) | ALDH1A1KDM4ELMNAGRIN1GRIN2B | |
| SCHEMBL19569439 | 0.87 | ATF4 (0.42) | ALDH1A1KDM4ELMNAGRIN1GRIN2B | |
| SCHEMBL30024960 | 0.85 | ATF4 (0.59) | ALDH1A1KDM4ELMNAGRIN1GRIN2B | |
| SCHEMBL19555405 | 0.85 | ATF4 (0.59) | ALDH1A1KDM4ELMNAGRIN1GRIN2B | |
| SCHEMBL19569443 | 0.83 | ATF4 (0.60) | ATF4 | |
| SCHEMBL19569304 | 0.82 | ATF4 (0.49) | ALDH1A1LMNAATF4GAA | |
| SCHEMBL20999266 | 0.82 | ATF4 (0.48) | ALDH1A1KDM4ELMNAGRIN1GRIN2B | |
| SCHEMBL19569273 | 0.81 | ATF4 (0.44) | ALDH1A1KDM4ELMNAGRIN1GRIN2B | |
| SCHEMBL19569272 | 0.81 | PPARG (0.43) | ALDH1A1KDM4ELMNAGRIN1GRIN2B | |
| SCHEMBL20974287 | 0.79 | ATF4 (0.64) | GRIN1GRIN2BATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |