Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | ATF4 | P18848 | 8/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555317 | 0.92 | ATF4 (0.48) | RAB9AP2RX7P2RY12ATF4TSHR | |
| SCHEMBL19569741 | 0.89 | MRGPRX4 (0.46) | RAB9AATF4MRGPRX4TSHRNPC1 | |
| SCHEMBL22669379 | 0.87 | RAB9A (0.42) | RAB9AP2RX7P2RY12MRGPRX4TSHR | |
| SCHEMBL20999329 | 0.85 | RAB9A (0.41) | RAB9ATSHRNPC1LMNAMAPT | |
| SCHEMBL25812778 | 0.85 | MRGPRX4 (0.43) | RAB9AATF4MRGPRX4TSHRNPC1 | |
| SCHEMBL27224194 | 0.81 | ATF4 (0.37) | RAB9AP2RX7P2RY12ATF4TSHR | |
| SCHEMBL22656715 | 0.80 | ALDH1A1 (0.43) | RAB9AATF4TSHRNPC1LMNA | |
| SCHEMBL30025980 | 0.78 | ATF4 (0.64) | ATF4TSHRALDH1A1HPGD | |
| SCHEMBL19569617 | 0.78 | ATF4 (0.64) | ATF4TSHRALDH1A1HPGD | |
| SCHEMBL20974037 | 0.78 | ATF4 (0.56) | RAB9AATF4MRGPRX4TSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |