Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ATF4 | P18848 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569741 | 0.95 | MRGPRX4 (0.46) | MRGPRX4ALDH1A1HPGDTSHRATF4 | |
| SCHEMBL19569744 | 0.85 | RAB9A (0.43) | MRGPRX4ALDH1A1HPGDTSHRATF4 | |
| SCHEMBL20974037 | 0.83 | ATF4 (0.56) | MRGPRX4ALDH1A1HPGDTSHRATF4 | |
| SCHEMBL19569725 | 0.81 | ATF4 (0.57) | MRGPRX4ALDH1A1HPGDTSHRATF4 | |
| SCHEMBL19569767 | 0.81 | ATF4 (0.54) | MRGPRX4ALDH1A1HPGDTSHRATF4 | |
| SCHEMBL20973906 | 0.81 | ATF4 (0.53) | MRGPRX4ALDH1A1HPGDTSHRATF4 | |
| SCHEMBL30025279 | 0.81 | ATF4 (0.50) | MRGPRX4ALDH1A1HPGDTSHRATF4 | |
| SCHEMBL22397113 | 0.80 | ATF4 (0.69) | ALDH1A1HPGDTSHRATF4KMT2A | |
| SCHEMBL20974272 | 0.80 | ATF4 (0.51) | MRGPRX4ALDH1A1HPGDTSHRATF4 | |
| SCHEMBL20973828 | 0.80 | ALDH1A1 (0.49) | MRGPRX4ALDH1A1HPGDTSHRATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |